The kinase and SH3/SH2 interaction domains of BTK bind, respectively, the DEAD-box domain of DDX41 and transmembrane region of STING. The CMV promoter drives the expression of the full-length NanoLuc® kinase fusion protein. Overexpression of constitutive-active BTK (E41K) further synergizes with STING to induce ifnb promoter activity, whereas overexpression of kinase-dead BTK (K430R) did not. Free Webinar, Catalog number selected:
Please check your network settings and try again. After that, you will need to contact Customer Service to unlock your account. BTK contains five different protein …
Please try again or contact Customer Service. five structures, K12R, K19E, R28C/H, and E41K mutants, were classified as "functional mutations," whereas L11P, S14F, F25S, and Y40N were grouped into "folding mutations" Data indicate Bruton's tyrosine kinase (Btk) as a key molecule in TLR9 signaling in plasmacytoid dendritic cells (PDCs) and the TLR7 and TLR9 pathways can be dissociated in PDCs. BTK plays a crucial role in B cell development. Enter your username and we'll send a link to reset your password. Our website uses functional cookies that do not collect any personal information or track your browsing activity.
By creating an account, you confirm that you accept the, Plate Readers, Fluorometers & Luminometers, Privacy Policy and Requests for Information, Transfection-ready DNA to express full-length BTK(E41K) kinase fused to NanoLuc® Luciferase, Measures kinase target engagement in live cells, Use with NanoBRET™ TE Intracellular Kinase Assay, Adherent Format protocol, Recommended Assay: NanoBRET™ TE Intracellular Kinase, K-10. You've created a Promega.com account. A password reset email has been sent to the primary email address associated with your account. NanoLuc® ORF TE Vector Limited Use Label License. U.S. Pat.
Nos. Edward Smith) and then subcloned into pMIG (a gift from William Hahn, Addgene plasmid 9044). To protect your privacy, your account has been locked after 6 failed login attempts. PROMEGA MAKES NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, EITHER EXPRESSED OR IMPLIED, INCLUDING FOR MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, WITH REGARD TO THE PRODUCT. Please try again or contact Customer Service. Trademarks.
Enter your username and we'll send a link to reset your password. BTK gene cause agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Our customer and technical support experts are here to help!
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(1a) use Nano-Glo®-branded luminescent assay reagents (LARs) for all determinations of luminescence activity of this product; or If researcher is not willing to accept the terms of this label license, and the product is unused, Promega will accept return of the unused product and provide researcher with a full refund. There was an issue resetting your password.
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Your commerce experience may be limited. BY USE OF THIS PRODUCT, RESEARCHER AGREES TO BE BOUND BY THE TERMS OF THIS LIMITED USE LABEL LICENSE. To protect your privacy, your account has been locked after 6 failed login attempts.
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Please check your network settings and try again. Researcher shall have no right to modify or otherwise create variations of the nucleotide sequence of the luciferase gene. U.S. Pat. The NanoBRET™ Tracer used is determined by your choice of NanoLuc® kinase fusion vector. Let's find the product that meets your needs.
Similarly, kinase-NanoLuc® implies NanoLuc® is 3´to the kinase gene (at the C-terminus of the kinase).
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