But unpublished data from the EXCEL trial seen by Newsnight has raised doubts about this conclusion. (UPDATED) The EXCEL investigators have responded to allegations that they concealed critical data during the pivotal study of PCI versus surgery for left main coronary artery disease and persisted with the trial despite concerns raised by the data and safety monitoring board (DSMB). The researchers carrying out the trial have agreed to an "independent" review of the raw data. Will the Chancellor's Job Support Scheme curb the rise in unemployment? No. Chuck D on racism in the US, Black Lives Matter and President Trump. Read about our approach to external linking. European clinical guidelines on how to treat a major form of heart disease are under review following a Newsnight investigation. The news programme BBC Newsnight has made further claims that the EXCEL investigators “held back” data from the published results of the left main trial. Some were recruited in 2011, others over the years that followed. But the review was not shared with everyone who believed they should have seen it. Even without this additional data, there was disagreement among those writing the guidelines about whether stents or surgery was the better treatment for patients. All the main doctors working on the trial, and the lead doctor writing the guidelines for left main disease, have declared financial contributions to either themselves or their institutions from companies that manufacture stents. It said that the evidence suggested stents were worse than surgery for those with left main disease. Newsnight has seen the review. They design the trials. The researchers said our leak data was fake and their methodology was the right one. By continuing to use our site, you are agreeing to our use of cookies. It showed that under one definition, patients in the trial with stents had 80% more heart attacks after three years. The Excel trial was a comparative trial of stents vs surgery in patients with disease Emails from the the trial's safety committee warned that all the data about deaths should be viewed by the researchers and published. On December 9th, BBC Newsnight came out with an investigation questioning the validity of the 2016 EXCEL clinical trial, led by Dr Gregg Stone, published in the New England Journal of Medicine. But unpublished data from the EXCEL trial seen by Newsnight has raised doubts about this conclusion. Professor Adrian Banning, President of the British Cardiovascular Intervention Society, Mr Richard Page, President of the Society of the Society of Cardiothoracic Surgeons, Professor Simon Ray, President of the British Cardiovascular Society, Society for Cardiothoracic Surgery in Great Britain & Ireland
"I'm absolutely appalled that they've done this," he said. These guidelines recommend both stents and heart surgery for certain patients with left main disease. Various names have been put forward by the researchers and the European Society of Cardiology about who is doing the analysis. The Excel trial – BBC Newsnight, 9 December 2019 . US Election 2020: Will Arizona turn its back on the Republican Party? Only after the guidelines were written did the researchers publish findings that showed increased mortality - 10% of those who’d had open heart surgery had died versus 13% of those with stents after 5 years. The Excel trial tested whether stents were as effective as open heart surgery at treating patients with a heart problem called left main disease.
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