Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. The American Heritage® Science Dictionary In the case of the gene for eye color, for example, one allele codes for blue eyes, whereas the other may code for brown eyes. “Affect” vs. “Effect”: Use The Correct Word Every Time, 10 Types Of Nouns Used In The English Language. The American Heritage® Stedman's Medical Dictionary There can be several variations of this sequence, and each of these is called an allele. The sequence of nucleotides on a DNA molecule that constitutes the form of a gene at a specific spot or a chromosome. Allele definition, any of several forms of a gene, usually arising through mutation, that are responsible for hereditary variation. A common premutation occurs in the Fragile X syndrome, in which ancestors of affected children may have 50 — 200 copies of the trinucleotide sequence CGG. 1991; Rousseau et al. The full mutation is defined as over 200 CGG repeats. Dictionary.com Unabridged
1991). (pre?mu-ta'shun) A sequence of multiply repeated nucleotides that may produce a disease in one's offspring but may not produce clinically apparent disease in the carrier. The normal repeat length is 5–44 CGG triplets; ‘gray zone’ alleles are defined as 45–54, premutation alleles as 55–200, and full mutations as above 200 CGG repeats. “Karen” vs. “Becky” vs. “Stacy”: How Different Are These Slang Terms? In almost all animal cells, two alleles for each gene are inherited, one from each parent. The New Dictionary of Cultural Literacy, Third Edition
(A normal FMR1 gene has 6-54 CGG repeats.) Second, following the discovery of the FMR1 gene, the premutation (allele) was defined by repeat-length instability leading to expansion to a full mutation (Fu et al. Repeat lengths in the gray zone may occasionally be unstable, or expand, when passing from one generation to … A premutation carrier is an individual, male or female, who has between 55-200 CGG repeats in the Fragile X (FMR1) gene. Do you remember all the words from last week, September 21–27, 2020?
any of two or more variants of a gene that have the same relative position on homologous chromosomes and are responsible for alternative characteristics, such as smooth or wrinkled seeds in peas. Published by Houghton Mifflin Harcourt Publishing Company. having or characterized by persistent or earnest desire. However, this definition has remained imprecise, resulting in definitions of the lower bound of the premutation with a range of 50–60 CGG repeats. Based on the Random House Unabridged Dictionary, © Random House, Inc. 2020, Collins English Dictionary - Complete & Unabridged 2012 Digital Edition One member of a pair or series of genes that occupies a specific position on a specific chromosome. Published by Houghton Mifflin Company. Why Do “Left” And “Right” Mean Liberal And Conservative? Genetic analysis of human families has revealed the involvement of premutations in several genetic diseases. Paired alleles (one on each of two paired chromosomes) that are the same are called. What Is The Difference Between “It’s” And “Its”? Absentee Ballot vs. Mail-In Ballot: Is There A Difference? any of several forms of a gene, usually arising through mutation, that are responsible for hereditary variation. Copyright © 2011. Then this quiz should be butyraceous. © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Democrats And Republicans: Why Are They Donkeys And Elephants? All rights reserved.
Copyright © 2005 by Houghton Mifflin Harcourt Publishing Company. expressive of or characterized by sorrow. See more. “Infamous” vs. “Notorious”: Which One Is Better? premutation A gene variant (allele) that produces a normal individual but is predisposed to become a full mutation in subsequent generations. Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012.
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Any of the possible forms in which a gene for a specific trait can occur.
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